Slay the Spire 2 Potion Relics Guide — Every Potion-Slot and Potion-Payoff Relic

Potions are free wins stored in glass — and a whole relic economy exists to give you more glass. This guide covers every potion-related relic worth knowing in Slay the Spire 2, sorted by what they actually do: capacity, supply, payoff, and the two relics that pay you to quit potions entirely.

Capacity: more slots, more options

• Potion Belt (Common) — upon pickup, gain 2 potion slots. The baseline expansion; the first pick of any potion-oriented run.
• Alchemical Coffer (Ancient, Orobas pool) — gain 4 slots filled with random potions. Capacity plus instant inventory; the strongest single potion relic in the game.

Supply: keep the bottles coming

• White Beast Statue (Rare) — potions always appear in combat rewards. Converts every normal fight into a chance at gas, and elites into potion fountains.
• The Cauldron (Shop) — upon pickup, brews 5 random potions. A one-time stockpile; best bought right before a hard act.
• Mailbox-style relics — rest-site potion drops reward routes that path through campfires; pair with a slot relic so the drops have somewhere to go.

Payoff: potions that hit back

• Reptile Trinket (Uncommon) — whenever you use a potion, gain 3 Strength this turn. The best payoff relic for any deck with attack turns: a healing potion becomes a damage card.
• Petrified Toad (Uncommon) — at the start of each combat, procure a Potion-Shaped Rock — a throwable that deals chunk damage to open the fight. Free board-clear tempo, every combat.

The two heresies: anti-potion relics

• Buckle-style relics — while you have no potions, gain Dexterity. A defensive build that never buys potions converts abstinence into block.
• Energy-for-abstinence relics — trade the entire potion system for +1 energy per turn. High-cost curve decks that never touched potions anyway lose nothing and gain an energy relic's worth of tempo.

Both are only correct if your deck genuinely ignores potions — taking them "for the stats" into a potion-relic run is burning slots.

Priority order

1. Capacity first: Potion Belt, then Alchemical Coffer. Empty slots are potential; filled slots are wins.
2. Supply second: White Beast Statue on combat-heavy routes; The Cauldron as a pre-boss purchase.
3. Payoff third: Reptile Trinket on any deck that ends fights with attack damage.
4. The heresies last, and only for decks that truly never drink.

Keep reading:

• Orobas Relic Priority
• The Boot Relic Guide
• Map Room Types and Route Planning